however = por más qué, no obstante
However hard he works, he would never get rich.
Por más que trabaje, nunca será rico.
We will hardly become champion however hard we try.
Por más que tratemos, nunca seremos campeones.
However bad the stock exchange looks, he is always on the winning side.
No importa lo mal que esté la bolsa, él siempre está al lado de los ganadores.